۱۳۹۵/۰۲/۱۴ (تعداد بازدید : ۱۲۳۷)نویسنده : Zahra Rezaieyazdi, Tahmine Tavakoli, Mohammad Khajehdaluee and Shahram Honarmand
Background: Mycophenolate mofetil (MMF) has long been used to manage lupus nephritis. Despite research on its
long-term efficacy, it is still warranted to conduct further investigation regarding its indications, safety and outcome.
This study was intended to evaluate our proposed protocol in maintenance therapy with MMF.
Twenty-four lupus nephritis patients were registered prior to their receiving ۳–۶ month induction therapy with
monthly iv pulses of cyclophosphamide (CYC), followed by ۲۴ month maintenance therapy using MMF and steroid.
We defined end points as achievement of complete and partial remission, relapse, refractory to therapy as well as
end stage renal disease (ESRD) and death. Friedman and repeated measurement tests were used to assess the
effect of treatment on parameters over time.